Piece of cake! Backing up to an external drive (be it a hard drive, thumb drive, flash card or whatever) is one of the standard backup menu options in PP4. I assume the same is true of PP5, but I can’t personally vouch for that. In general, I like PP4 and it meets most routine collection management needs quite well. Also, and importantly, the support staff is very helpful. They speak plain English, and they’re patient in dealing with folks who aren’t very techno-savvy.